The development by a disease-causing microbe, through mutation or gene transfer, of the ability to survive exposure to an antimicrobial agent that was previously an effective treatment.
Increased antimicrobial resistance (AMR), or antibiotic resistance, is a critical One Health issue that has resulted in policies to reduce antibiotic use in food production animals. However, there is little quantification of the public health effects of such initiatives. Our study used beef as a model to quantify trends in the longitudinal relationship between human nontyphoidal salmonellosis and antibiotic-resistant nontyphoidal Salmonella in meats. Our risk assessment also tested the effect of removing antibiotic use from all beef cattle production which returned some interesting results.
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